c-erbB-2 protein expression in astrocytic tumors of the brain

c-erbB-2 protein expression in astrocytic tumors of the brain

BACKGROUND Astrocytic tumors are the primary brain tumors, which often progress to glioblastoma, a highly malignant neoplasm of the central nervous system. There is much new data regarding to the formation and progression of these tumors; however, glioblastoma remains one of the most fatal neoplasms in humans. The aim of the study was to evaluate the role of c-erbB-2 protein expression in vario...

High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2.

The erbB-2 (or HER-2 or neu) gene is amplified and overexpressed in approximately one-third of cancers of the breast, stomach, and ovary. Evidence is accumulating that erbB-2 overexpression is associated with decreased survival of breast cancer patients. In an effort to understand how erbB-2 overexpression might impart a more malignant potential to breast cancer cells, we have searched for evid...

Comments on the paper "c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors".

Amplification of c-erbB-2 and aggressive human breast tumors?

well as allelic deletions ofgenes on chromosomes 11 or 13 (9, 10). The frequency and level of amplification of c-myc and c-erbB-2 proto-oncogenes vary between different groups of patients studied by different laboratories. Amplification of c-erbB-2 was reported in 10, 16, 18, and 40% of breast tumors from different groups of patients (2, 5-8). In one study this proto-oncogene was suggested as a...

An Immunohistochemical Study of Cyclin D1 Expression in Astrocytic Tumors and its Correlation with Tumor Grade

Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential target for therapeutic intervention. The aim of the present study was to determine...